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祝贺周敏在Organic Letters期刊发表关于ArOCF3合成的论文
发布时间:2016/7/22

O‑Trifluoromethylation of Phenols: Access to Aryl Trifluoromethyl Ethers by O‑Carboxydifluoromethylation and Decarboxylative Fluorination 
Zhou, Min; Ni, Chuanfa; He, Zhengbiao; Hu, Jinbo*
Organic Letters, 2016, 18, 3754 – 3757.
 

Abstract:

       A new strategy for the synthesis of aryl trifluoromethyl ethers (ArOCF3) by combining O-carboxydifluoromethylation of phenols and subsequent decarboxylative fluorination is reported. This protocol allows easy construction of functionalized trifluoromethoxybenzenes and trifluoromethylthiolated arenes (ArSCF3) in moderate to good yields. Moreover, it utilizes accessible and inexpensive reagents sodium bromodifluoroacetate and SelectFluor II and, thus, is practical for O-trifluoromethylation of phenols. The potential application of this method is demonstrated with the preparation of a plant-growth regulator, Flurprimidol.

 

第一作者简介:

周敏,2014年6月在本课题组获得专业硕士学位,目前在本课题组攻读博士学位,主要研究三氟甲基醚的合成。






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