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祝贺陈定奔在Angewandte Chemie发表论文
发布时间:2016/9/8

Bis(difluoromethyl)trimethylsilicate Anion: A Key Intermediate in Nucleophilic Difluoromethylation of Enolizable Ketones with Me3SiCF2H 
Chen, Dingben; Ni, Chuanfa; Zhao, Yanchuan; Cai, Xian; Li, Xinjin; Xiao, Pan; Hu, Jinbo*
Angew. Chem., Int. Ed. 2016, 55, 12632 – 12636.
 

Abstract:

       A pentacoordinate bis(difluoromethyl)silicate anion, [Me3Si(CF2H)2]-, is observed for the first time by the activation of Me3SiCF2H with a nucleophilic alkali-metal salt and 18-crown-6. Further study on its reactivity by tuning the countercation effect led to the discovery and development of an efficient, catalytic nucleophilic difluoromethylation of enolizable ketones with Me3SiCF2H by using a combination of CsF and 18-crown-6 as the initiation system. Mechanistic investigations demonstrate that [(18-crown-6)Cs]+[Me3Si(CF2H)2]- is a key intermediate in this catalytic reaction.

 

第一作者简介:

陈定奔,台州学院副教授,从2014年9月开始,在本课题组进行博士后研究。主要研究亲核氟烷基化反应及其机理。

 


 






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